The Clearlake Highway Patrol's incident logs reported that the vehicle-versus-cow collision occurred at 7:32 p.m. on southbound Highway 29, two miles north of Middletown.
The black cow was reportedly dead at the scene, found on the road's west shoulder, according to the CHP.
A rancher who may have owned the cow and Caltrans were reportedly on their way to the scene to remove the animal, CHP reported.
No information was available about the vehicle involved.
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